Functional genetics in inborn errors of immunity
نویسندگان
چکیده
منابع مشابه
Inborn errors of immunity to infection
The immune system's function is to protect against microorganisms, but infection is nonetheless the most frequent cause of death in human history. Until the last century, life expectancy was only approximately 25 years. Recent increases in human life span primarily reflect the development of hygiene, vaccines, and anti-infectious drugs, rather than the adjustment of our immune system to coevolv...
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(active) and Ab-mediated (passive) enhancement. The opsonization of antigen recognition cells versus production of anti-idiotypic antibody theories of passive enhancement are then presented and evaluated. Subsequent chapters, excellent in depth and coverage, deal with: (i) the role and possible mechanisms of action of antiidiotypic antisera on Band T-lymphocytes; (ii) the use of donor-specific ...
متن کاملGarrod's Inborn Errors of Metabolism
Dr. Van Liere's earlier book on this subject* was probably the first detailed study of the biology of low oxygen pressure. Investigations of the effect of high altitude, using mountain climbing or balloon ascent as a tool, go back to the late eighteenth century, but the major impetus seems to have been the need for military aviation in World War I. This interest was maintained until about 1935 ...
متن کاملInborn errors of sterol biosynthesis.
The known disorders of cholesterol biosynthesis have expanded rapidly since the discovery that Smith-Lemli-Opitz syndrome is caused by a deficiency of 7-dehydrocholesterol. Each of the six now recognized sterol disorders-mevalonic aciduria, Smith-Lemli-Opitz syndrome, desmosterolosis, Conradi-Hünermann syndrome, CHILD syndrome, and Greenberg dysplasia-has added to our knowledge of the relations...
متن کاملInborn errors of metabolism: iron.
The iron content of the body is normally closely regulated. Despite this, iron deficiency anaemia is common in women because iron losses due to menstruation and childbirth are not always compensated for by iron absorption from the diet. The role of transferrin in delivering iron to cells and of ferritin in storing iron within cells is well understood but the proteins involved in iron transport ...
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ژورنال
عنوان ژورنال: Future Rare Diseases
سال: 2021
ISSN: 2399-5262,2399-5270
DOI: 10.2217/frd-2020-0003